(Turn and face the strange*)
This program addresses how orofacial motor actions that underlie exploration, with current emphasis on the lingual, nasal, and vibrissa sensorimotor systems, encode a stable world view through the coordinated movement of sensory organs and sensors. It includes anatomical, behavioral, and electrophysiological components.
This program explores the structure and, vasodyanmic, and neurodynamic control of blood flow in the brain. This program includes anatomical, computational, and opto- and electrophysiological components. We further study the consequences of interruptions to cortical blood flow at the level of individual microvessels as a means to understand the neuroimflammation and nmicrostrokes.
This program creates new tools for our scientific studies. We currently focus on: (1) imaging of cortical axons and spines deep within brain tissue through the use of adaptive optics with two-photon microscopy; (2) construction of an active digital atlas of the mouse brain, with current emphasis on the brainstem; and (3) volition control of neuromodulation in the brains of behaving animals using nanoMolar affinity cell-based molecular sensors. This program has strong imaging and computational components.