Neurophysics Research

(Turn and face the strange*)

Active sensing:

This program addresses how orofacial motor actions that underlie exploration and foraging, with current emphasis on the lingual, vibrissa, and heading  sensorimotor systems, encode a stable world view through the coordinated movement of sensory organs and sensors. It includes decoding of vibrissa touch in the presence of self-movement. Our program is motivated by a desire to discover engineering-like principles that explain the design and function of a nervous systems within the confines of rodent-based experiments. The program includes anatomical, behavioral, computational, functional imaging, electro- and opto-physiological, and theoretical  components.

Microcirculation within the brain:

This program explores the vascular connectome for the brain and neuronal and vascular control of blood flow throughout the brain. Simply, how does nature ensure adequate flow throughout the half-kilometer of microvessels - in a mouse brain - given vasomotion and changes in metabolic load and neurological state. We further address the consequences of interruptions to flow at the level of individual microvessels as a means to understand microstrokes and aspects of neuroinflammation. This program includes anatomical, computational, electro- and opto-physiological, and functional imaging components.

Neurotechnology:

We maintain an ongoing effort to develop tools that advance our scientific studies. We currently focus on: (1) imaging of somas, axons, and spines deep within structurally complex tissue, like the brainstem, through the use of adaptive optics with novel guide-stars and two-photon microscopy; and (2) construction of an active digital atlas of the mouse brain and automated registration based on microscopic texture of brain tissue, with current emphasis on the brainstem.


Neurophysics-Feb-2020 missing Celine

*David Bowie, 1947-2016