(Turn and face the strange*)
This program addresses how orofacial motor actions that underlie exploration, with current emphasis on the lingual, nasal, and vibrissa sensorimotor systems, encode a stable world view through the coordinated movement of sensors. It includes anatomical, behavioral, and electrophysiological components.
This program explores the structure and neuronal control of blood flow in the brain, and variations and interruptions in that flow, at the level of brain-wide vascular networks down to that of individual microvessels. It includes anatomical, computational, and opto- and electrophysiological components.
This program creates new tools for our scientific studies. We currently focus on: (1) deep imaging of cortical axons and spines using adaptive optics with two-photon microscopy; and (2) volume transmission of cell-signaling molecules as neuromodulation in the brains of behaving animals measured with CNiFERs, nanoMolar affinity cell-based molecular sensors.